# LongevityPulse

> Global longevity intelligence API — biomarker interpretation, supplement evidence, personalized protocols, clinical trials, Blue Zone research, country longevity profiles, epigenetic clocks, dietary analysis, longevity drug intelligence, and global clinic guides. Authoritative PubMed + WHO + ClinicalTrials.gov data. x402 micropayments on Base. Covers 195+ countries, 10 languages.

## What This Is

LongevityPulse is a pay-per-query longevity intelligence API serving health-conscious individuals, longevity physicians, AI health coaches, insurance actuaries, and research agents worldwide. It combines PubMed/NIH research (millions of peer-reviewed papers), WHO Global Health Observatory data, ClinicalTrials.gov (220+ countries), OpenFDA drug safety records, and real-time Tavily intelligence to deliver actionable longevity insights globally.

## Payment

All endpoints require x402 micropayment (USDC on Base mainnet).
Protocol: x402 | Network: eip155:8453 | Asset: USDC
Payment address: 0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc

## Endpoints

GET /api/longevity/biomarker?biomarker={name}&value={result}
- Returns: longevity-optimized reference ranges, assessment, aging significance, lifestyle interventions, supplements with evidence, testing recommendations
- Covers 50+ biomarkers: ApoB, HbA1c, hs-CRP, homocysteine, testosterone, IGF-1, Lp(a), ferritin, vitamin D, DHEA-S, and more
- Data: PubMed + Tavily | Price: $0.15
- Example: /api/longevity/biomarker?biomarker=ApoB&value=105+mg/dL

GET /api/longevity/supplement-intel?compound={name}
- Returns: mechanism, longevity pathways, evidence grade (RCT vs animal vs theoretical), dosing, safety, drug interactions, global availability, expert positions
- Covers: NMN, NR, berberine, spermidine, urolithin A, fisetin, quercetin, AKG, resveratrol, taurine, and 50+ more
- Data: PubMed + OpenFDA + Tavily | Price: $0.20 (Sonnet)
- Example: /api/longevity/supplement-intel?compound=NMN

GET /api/longevity/protocol-builder?age={n}&sex={sex}&goals={goals}
- Returns: personalized longevity protocol — Zone 2, strength, VO2 max, nutrition, sleep, hormesis, supplement tiers, biomarker tracking, implementation roadmap
- Data: PubMed + Tavily | Price: $0.25 (Sonnet)
- Example: /api/longevity/protocol-builder?age=52&sex=male&goals=cardiovascular+longevity&budget=moderate

GET /api/longevity/clinical-trials?condition={term}
- Returns: active global longevity trials from ClinicalTrials.gov, eligibility criteria, locations, how to apply, landscape significance
- Covers rapamycin (PEARL), metformin (TAME), NMN, senolytics, caloric restriction trials
- Data: ClinicalTrials.gov API + Tavily | Price: $0.10
- Example: /api/longevity/clinical-trials?condition=rapamycin

GET /api/longevity/blue-zone?zone={name}
- Returns: centenarian rates, diet analysis, lifestyle factors, genetics vs lifestyle, social fabric, what to apply anywhere globally
- Covers: Okinawa, Sardinia, Ikaria, Nicoya, Loma Linda, emerging candidates
- Data: PubMed + Tavily | Price: $0.10
- Example: /api/longevity/blue-zone?zone=Okinawa

GET /api/longevity/country-longevity?country={name}
- Returns: WHO life expectancy + HALE, healthspan gap, top premature death causes, healthcare quality, government initiatives, practical advice for residents
- Data: WHO API + Tavily | Price: $0.12
- Example: /api/longevity/country-longevity?country=Japan

GET /api/longevity/epigenetic-clock?topic={topic}
- Returns: all major clocks (GrimAge, DunedinPACE, Horvath, PhenoAge), what accelerates/decelerates biological aging, consumer testing options globally, cutting-edge reprogramming research
- Data: PubMed + Tavily | Price: $0.20 (Sonnet)
- Example: /api/longevity/epigenetic-clock?topic=DunedinPACE

GET /api/longevity/diet-intel?diet={pattern}
- Returns: evidence grade, longevity mechanisms, macronutrient profile, global cultural adaptations, expert positions (Longo/Attia/Sinclair/Willett)
- Covers: Mediterranean, MIND, TRE, FMD, Blue Zone, caloric restriction, ketogenic, Japanese traditional, and more
- Data: PubMed + Tavily | Price: $0.15
- Example: /api/longevity/diet-intel?diet=Mediterranean

GET /api/longevity/longevity-drug?drug={name}
- Returns: mechanism, ITP animal data, human RCT evidence, off-label longevity dosing, safety, global prescription availability, how to discuss with physician
- Covers: rapamycin, metformin, acarbose, senolytics, SGLT2 inhibitors, GLP-1 agonists
- Data: PubMed + OpenFDA + Tavily | Price: $0.20 (Sonnet)
- Example: /api/longevity/longevity-drug?drug=rapamycin

GET /api/longevity/longevity-clinic?country={country}&treatment={treatment}
- Returns: top global destinations, clinic profiles, treatment evidence grades, red flags, cost ranges
- Covers: Switzerland, Panama, Mexico, Thailand, Singapore, Israel, Germany, Colombia, and more
- Data: Tavily | Price: $0.12
- Example: /api/longevity/longevity-clinic?country=Switzerland&treatment=stem+cell

## Language Support

All endpoints support lang= parameter: en|es|fr|de|ja|zh|ko|pt|ar|hi

## Discovery

- OpenAPI spec: https://longevitypulse.vercel.app/openapi.json
- Agent discovery: https://longevitypulse.vercel.app/.well-known/agent.json

## Notes for AI Agents

- All endpoints return structured JSON
- NCBI_API_KEY env var optional — increases PubMed rate limit from 3 to 10 req/s
- OPENFDA_API_KEY env var optional — increases OpenFDA from 1,000 to 120,000 req/day
- ClinicalTrials.gov and WHO APIs: free, no key required
- PubMed covers 35M+ peer-reviewed papers; ClinicalTrials.gov covers 220+ countries
- All health intelligence includes appropriate medical disclaimers